Derivatives of cyclopentane fused to a benzene, thiophene or furan ring, processes for their preparation and their application in therapeutics

摘要

Compounds possessing antiviral activity of formula (I) or (II) where: - A represents a thiophene, furan or optionally substituted benzene ring; (X;Y) represents (CH2;CH2), (CO;CH2 or CR4R5 or CHOH or CHOR1), (CHOH;CH2 or CHOH), (CHOR1;CH2 or CHOR1), (CHOCONH(CH2)nHal;CH2), (CHOR2;CH2) or (C=NOR3;CH2); R1 = formyl or acyl; R2 = alkyl; R3 = H or alkyl; R4, R5 = H or halogen; - R = NH2, NHR6 (with R6 = R1), NHCOO<(-)>R7 (with R7 = <(+)>NH3-R8 where R8 represents C) or NHCONHR9 (with R9 = H or (CH2)nHal); - B represents an optionally salified <IMAGE> ring or <IMAGE> ring, in which case &rdurule& X' represents &rdurule& CO, &rdurule& CHOH or &rdurule& CHOCONH(CH2)nHal, or a ring D, in which case &rdurule& X' represents &rdurule& CO, &rdurule& CHOH, &rdurule& CHOR1 or &rdurule& C=NOR3. <IMAGE>