| 摘要 |
<p>PURPOSE:To chemically synthesize the subject compound by reacting a cyclopentene compound with an aminodihalopyrimidine, subjecting the obtained pyrimidine compound to imidazole cyclization reaction, converting the halogen group of the produced purine compound to amino group and deprotecting the product. CONSTITUTION:The objective compound is produced by reacting a cyclopentene compound of formula I (R'2 to R'4 are OH-protecting group) with a 5-amino-4,6- dihalopyrimidine, subjecting the resultant pyrimidine compound of formula II (X is halogen) to imidazole cyclization reaction to obtain a purine compound of formula III, converting the 6-halogeno group of the compound to amino group and eliminating the protecting groups of the 2'-, 3'- and 6-hydroxyl groups.</p> |
