| 发明名称 |
HORMONE ANALOGS WITH MULTIPLE CTP EXTENSIONS |
| 摘要 |
The invention provides peptide and protein pharmaceuticals with extended half-lives. The modified peptides and proteins of the invention contain at least two tandem extensions at their C-terminus comprising the carboxy terminal portion of human chorionic gonadotropin. These "CTP units" consist essentially of the native HCG- beta sequence from position 112-118 to position 145 or conservative modifications thereof. |
| 申请公布号 |
WO9306844(A1) |
申请公布日期 |
1993.04.15 |
| 申请号 |
WO1992US08424 |
申请日期 |
1992.10.02 |
| 申请人 |
WASHINGTON UNIVERSITY |
发明人 |
BOIME, IRVING |
| 分类号 |
C12N15/09;A61K38/00;A61K38/24;A61K39/395;C07K14/575;C07K14/59;C07K16/00;C07K16/26;C07K19/00;C12N1/19;C12N1/21;C12N5/10;C12N15/00;C12N15/16;C12P21/00;C12R1/91 |
主分类号 |
C12N15/09 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
