METHOD FOR GENETICALLY MODIFYING BONE MARROW CELLS OF PRIMATES, AND USEFUL CELLS THEREFOR THAT PRODUCE RECOMBINANT RETROVIRAL VECTORS

摘要

A method for genetically modifying bone marrow cells of primates, comprising isolating bone marrow cells from a primate and, by means of cocultivation, exposing the isolated bone marrow cells to cells that produce a recombinant amphotropic retrovirus with a genome based on a retroviral vector that contains the genetic information to be introduced into the bone marrow cells. Recombinant amphotropic retrovirus-producing cells, suitable for use in this method.