DEVICE FOR ADMINISTERING DRUG TRANSDERMALLY WITH A CONTROLLED TEMPORAL CHANGE IN SKIN FLUX

摘要

2120508 9306803 PCTABS00021 A transdermal drug delivery device (10) that administrers drug in an initial pulse followed by a substantially lower continuous rate comprising an impermeable backing layer (11), a drug reservoir (13) of the drug dissolved in a nonvolatile skin permeation enhancer and a volatile permeation enhancer confined between a backing (12) that is permeable to the volatile permeation enhancer and an underlying substrate layer (12) that is permeable to the drug and both enhancers. When the device (10) is placed on the skin the volatile permeation enhancer is depleted from the reservoir (13) by evaporation through the backing (12) such that the magnitude and duration of the pulse is dependent upon the permeability of the backing layer (12) to the volatile enhancer. A pressure sensitive adhesive layer (15) and a release liner (16) are also provided.