NEW CONJUGATES FOR THE INTRODUCTION OF NUCLEIC ACID INTO HIGHER EUKARYOTIC CELLS

摘要

The invention concerns conjugates for inserting gene constructs into higher eukaryotic cells, the conjugates comprising a virus bound via an antibody to a substance having affinity for nucleic acid. Complexes of the conjugates with nucleic acid are internalized into the cell, optionally with the assistance of a cell-type-specific internalization factor, the virus causing, as a component of the complex, the internalization and the liberation of the content of the endosomes in which the complexes are localized after entering the cell. The invention also concerns pharmaceutically preparations in which the nucleic acid is a therapeutically active gene construct, in particular preparations for use in gene therapy and transfection kits.