Infracellular vesicular vectors and their application in cosmetic and medical compositions and culture media.

摘要

These infracellular vesicular vectors which contain metabolic ligands capable of being expressed inside and outside their structure have a specific affinity for the fibroblast whose membrane composition, which is modified by the introduction of metabolic ligands, results in a modulation of the synthetic activity of the target cell. They are chosen from among the artificial vesicles, capsules or spheres with a diameter which may range from 30 to 1000 nanometers used to incorporate an active substance either into an aqueous medium which fills the internal volume of the vector or into the wall itself of the said vector and then to transport this active substance to a site where it will be liberated and used for various purposes. The active ingredients are encapsulated at concentrations ranging from 0.01% to 2% (10<-5> - 10<-2>) relative to the total lipid phase. The metabolic ligands are chosen from the initiators (fatty esters of ascorbic acid) and the modulators of cellular synthesis (collagen hydrolysate palmitate or fatty esters of hydroxyproline) which are provided with a lipophilic functional group or radical by acylation. They find applications in cosmetic compositions designed for toning up the skin tissue, for treating small indurated scars and small wrinkles, and for strengthening the epithelial layer, as well as in medicinal compositions designed to increase the synthesis of collagenases so as to resorb dense fibrous tissues into collagen I or to resorb cheloids, as well as to orient the synthesis of collagen towards a specific structure such as collagens I and III. Finally, they are applicable to the preparation of culture media for the production of peptides of the extracellular matrix and for the production of enzymatically active peptides.