Oxazole and imidazole derivatives as prostaglandin analogs.

摘要

Thromboxane receptor antagonist activity is exhibited by compounds of the formula wherein: V is -(CH<6>)m-, -O-, or but if V is -O- or R<3> and R4 must complete an aromatic ring; W is -(CH<6>)<6>-, -CH=CH- or phenylene; X is a single bond, -CH=CH-, -(CH<6>)n-, or -O-(CH<6>)n-; or X is branched alkylene or -O-branched alkylene wherein W is linked to Y through a chain n carbon atoms long; Y is -CO<6>H, -CO<6>alkyl, -CO<6>alkali metal, -CH<6>OH, -CONHSO<6>R5, -CONHR6, or -CH<6>-5-tetrazolyl; Z is O or NH; R<3> and R4 are each independently hydrogen or alkyl or R<3> and R4 together complete a ring optionally substituted through a ring carbon with a halo, lower alkyl, phenyl, halo (lower alkyl), halophenyl, oxo or hydroxyl group; and the remaining symbols are as defined in the specification.