| 摘要 |
PCT No. PCT/SE94/00331 Sec. 371 Date Oct. 11, 1995 Sec. 102(e) Date Oct. 11, 1995 PCT Filed Apr. 14, 1994 PCT Pub. No. WO94/23703 PCT Pub. Date Oct. 27, 1994Porous cellulose matrices with a defined particle size and a significantly higher porosity (i.e. pore volume) than conventional formulations, such as pellet formulations containing cellulose and binders are prepared. The cellulose is mechanically treated with low adhesion to the process equipment during a controlled gradual addition of an aqueous based fluid, optionally containing a surface-active ingredient, into regular particles, which are finally dried to obtain dry porous cellulose matrices. The so obtained matrices can be used as carriers for bioactive substances in multiple-unit preparations or tablets. |
