Rapamycin analog as immunosuppressant

摘要

Reduction of the C-33 ketone of rapamycin gives the C-33 hydroxy analog of Formula I. <IMAGE> Formula I <IMAGE> The reduction product prevents cleavage of the C-31/C-32 bond due to base degradation. The Formula I compounds exhibit immunosuppressant, antifungal, and antiinflammatory activities.