The present invention relates to a process of converting partially purified taxane mixtures into Baccatin III. The process for the preparation of Baccatin III includes contacting a mixture containing at least one taxane compound having an ester linkage at the C-13 position with at least one borohydride reducing salt in a reaction solvent in the present of a Lewis acid.
申请公布号
US5202448(A)
申请公布日期
1993.04.13
申请号
US19920930840
申请日期
1992.08.14
申请人
NAPRO BIOTHERAPEUTICS, INC.
发明人
CARVER, DAVID R.;PROUT, TIMOTHY R.;EWALD, HERNITA A.;HENDERSON, DONIA L.