| 摘要 |
AHP-9836 BENZIMIDAZOLE PHOSPHONO-AMINO ACIDS The compounds of the formula <IMG> wherein R is hydrogen, lower alkyl, benzyl or pivaloyloxymethyl; R1 and R2 are, independently, hydrogen, lower alkyl, lower alkoxy, trifluoromethyl, trifluoromethoxy, methanesulfonylamino, acetylamino, or halo, or when taken together R1 and R2 represent a methylenedioxy grouping; and the pharmacologically acceptable salts thereof are NMDA antagonists useful in the treatment and prevention of central nervous system related pathological conditions resulting from overstimulation by excitatory amino acids.
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