| 摘要 |
Process for RNA synthesis consisting in successively condensing nucleosides of the formula (I) in which R<1> is a puric or pyrimidic optionally protected base, R<2> is a leaving group such as the dimethoxytrityl radical, R<3> is a phosphorus-containing radical, for example, phosphoramidite and R<4> is a trialkylsilyl radical. The RNA obtained is then subjected to a protective treatment with a reagent of the formula (II), for example N(C2H5)3, 3HF, to eliminate R<4> protective groups of the 2' hydroxyl groups. Such reagent provides full deprotection in about ten hours, with an RNA of great length, for example, having more than 50 bases.
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