Indole derivatives and anti-ulcer compositions.

摘要

Disclosed are indole derivatives of formula (I) <CHEM> wherein Y represents H, C<5>-C1/4 alkyl, C<5>-C1/4 alkoxy or halogen; Z represents -CH<6>N(R psi )-; R represents H or -CH<6>CH<6>X where X represents pyridyl, aralkyloxy or substituted amino of NR1/4 R1/2 where R1/4 represents H, C<5>-C1/4 alkyl, aralkyl, C<5>-C1/4 alkoxycarbonyl, aralkyloxycarbonyl or halogenated C<5>-C1/4 alkoxycarbonyl and R1/2 represents H, C<5>-C1/4 alkyl or aralkyl, or together with R<6> may form a ring of -(CH<6>)n- (n is 1-4) or <CHEM> R<5> represents H, C<5>-C1/4 alkyl, aralkyl or arylsulfonyl; R<6> represents C<5>-C1/4 alkyl, hydroxy, C<5>-C1/4 alkoxy or aralkyloxy; R<7> represents H, C<5>-C1/4 alkyl, aralkyl or halogenated C<5>-C1/4 alkyl; R<8> and R psi may be the same or different and each represents H, C<5>-C1/4 alkyl or aralkyl or both may together form a ring of -(CH<6>)m- (m is 3 or 4); or pharmaceutically acceptable acid addition salts thereof. They are useful as an antiulcer agent.