1,8-Benzonaphthyridine derivatives and antimicrobial compositions.

摘要

New 1,8-benzo[b]naphthyridine derivative of general formula: <IMAGE> in which R is H or a hydroxyl, amino or alkylamino radical, the alkylamino radical optionally being substituted with amino or hydroxyl, or R is dialkylamino in which the alkyl parts may form, with the nitrogen atom, a 5- or 6-membered heterocycle optionally containing another heteroatom chosen from nitrogen, oxygen or sulphur, or R is cycloalkylamino (3 to 6C), or an alkanoylamino, N-alkyl-N-alkanoylamino or aminoalkylphenylamino radical, R1 and R2, which are identical or different, are in position 2 and 3 and represent H, alkyl, alkenyl (2 to 4C), phenyl or substituted phenyl, or else R1 and R2 are in position 2 and represent alkyl, R3 is H or alkyl, fluoroalkyl, carboxyalkyl, cycloalkyl containing 3 to 6 carbon atoms, fluorophenyl, difluorophenyl, alkyloxy or alkylamino, and R4 is H or F, the alkyl and alkanoyl (1 to 4C) radicals being straight or branched, in its stereoisomeric forms or their mixtures as well as its salts and its hydrated forms. These new derivatives are useful as antimicrobial agents.