发明名称 |
3,4-Dehydropiperidine derivatives. |
摘要 |
<p>The invention relates to a group of new 3,4-dehydropiperidine derivatives of the formula <CHEM> wherein R<5> is a hydrogen atom or an alkyl group having 1-3 carbon atoms; Y is a group of the general formula 2 <CHEM> wherein R<6> is a group of the formula -(CH<6>)n-C(=X)-NR<7>R<8>, -(CH<6>)n-SO<6>-NR<7>R<8>, -(CH<6>)n-NR psi -C(=X)-R1/4 or -(CH<6>)n-NR psi -SO<6>-R1/4 , wherein R<7>, R<8> and R psi independent of each other represent hydrogen or alkyl (1-3C), R1/4 is alkyl (1-3C), X represents O or S; n is 0-4, and R is hydrogen or alkyl (1-3C). These compounds have interesting serotonin-1-like (partial) agonistic activity and can be used for the treatment of migraine.</p> |
申请公布号 |
EP0535722(A1) |
申请公布日期 |
1993.04.07 |
申请号 |
EP19920202082 |
申请日期 |
1992.07.08 |
申请人 |
DUPHAR INTERNATIONAL RESEARCH B.V |
发明人 |
HULKENBERG, ANTONIUS;VAN CHARLDORP, KARIN J.;VAN HES, ROLF;VAN WIJNGAARDEN, INEKE |
分类号 |
A61K31/435;A61K31/44;A61P25/04;C07D211/70;C07D333/52;C07D409/04 |
主分类号 |
A61K31/435 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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