发明名称 |
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摘要 |
A process and apparatus are provided for making hollow macrospherical particles. The particles themselves are particularly adapted for use as anti-perspirants. The particles have a diameter between about 10 and 74 microns, preferably predominating between 15 and 44 microns, and a greater than unit density. As such, they are not subject to deep lung penetration. The process for producing the particles comprises providing a solution containing the materials from which the particles are made, diffusing the solution through small pores by centrifugal force such that the resulting hollow particles have a diameter greater than the pore diameter, and drying the solution droplets in a stream of heated air. The apparatus for producing the macrospherical particles comprises a centrifugal atomizer having a porous sintered metal filter ring which is rotated inside a spray drying chamber. The filter is treated to produce hollow macrospheres having substantially smooth outer walls of such thickness that they can withstand normal shipment and handling without significant fragmentation. |
申请公布号 |
DE2725754(C2) |
申请公布日期 |
1993.04.01 |
申请号 |
DE19772725754 |
申请日期 |
1977.06.07 |
申请人 |
ARMOUR PHARMACEUTICAL CO., PHOENIX, ARIZ., US |
发明人 |
KOZISCHEK, JAMES F., BELVIDERE, N.J., US |
分类号 |
A61K33/06;A61J3/02;A61K8/00;A61K8/11;A61K8/26;A61K8/28;A61K8/34;A61K9/16;A61Q15/00;B01D1/18;B01J2/02;B01J2/04;B05B3/10;B29B9/00;C08J3/12 |
主分类号 |
A61K33/06 |
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