| 摘要 |
<p>A method of attenuating the symptoms of opioid withdrawal in a human or animal subject comprises administering to the subject an effective opioid withdrawal symptom attenuating amount of an inhibitor of nitric oxide synthase (NOS) for a period of time effective to attenuate such symptoms upon opioid withdrawal. NOS inhibitors useful in the present method include, for example, L-NG-nitroarginine, esters of L-NG-nitroarginine, L-NG-monomethylarginine, L-NG-benzylarginine, L-NG-aminoarginine, iminoethylornithine, and pharmaceutically acceptable salts thereof. These compounds can be used alone or in combination, in conjunction with conventional drugs, such as α¿2?-adrenoceptor agonists, mixed agonist-antagonist opioids, and NMDA antagonists, to attenuate the symptoms of opioid withdrawal. Effective doses of NOS inhibitors range from about 1 νg/kg/day to about 30mg/kg/day, administered over the course of about 1 hour to about six days, followed by opioid withdrawal.</p> |
