| 摘要 |
2118595 9306132 PCTABS00021 A process is disclosed for site-directed chemical modification of peptides and proteins that consists of two steps: (a) selective oxidation of a 2-hydroxyethylamine moiety, -CH(NH2)-CH(OH)-, in the peptide or protein to generate an aldehyde, and (b) reaction of the new aldehyde with a second reagent to form a product in which the native biological properties of the peptide are augmented by new and useful properties conferred by the second reagent. Additionally, the invention pertains to certain specified types of product formed by the above process.
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