发明名称 |
BIOLOGICALLY ACTIVE AMPHIPHILIC PEPTIDE COMPOSITIONS AND USES THEREFOR |
摘要 |
Biologically active amphiphilic peptides including one of the following basic structures: I) R1-R2-R2-R1-R2-R2-R1-R1-R2-R1-R1; II) R2-R1-R2-R2-R1-R1-R2-R2-R1-R2-R2; III) R1-R2-R2-R1-R1-R2-R2-R1-R2-R2-R1-R1-R2-R3; IV) R1-R2-R1-R1-R2-R2-R1-R1-R2-R2-R4; V) R1-R1-R2-R2-R1-R2-R2-R1-R1-R2-R2-R3; or VI) R1-R1-R3-R2-R1-R1-R1-R1-R1-R1-R2-R1-R1-R2-R2-R1-R1-R2-R2-R1. R1 is a hydrophobic amino acid and R2 is a basic hydrophilic or neutral hydrophilic amino acid, R3 is a neutral hydrophilic amino acid, and R4 is a neutral hydrophilic amino acid or proline. There is also provided a biologically active amphiphilic peptide having a structural formula selected from the group consisting of: (a) R1-R2-R2-R1-R2-R2-R1; (b) R1-R1-R2-R2-R1-R2-R2-R1; (c) R2-R1-R1-R2-R2-R1-R2-R2-R1; (d) R2-R2-R1-R1-R2-R2-R1-R2-R2-R1; and (e) R1-R2-R2-R1-R1-R2-R2-R1-R2-R2-R1, wherein R1 and R2 are hereinabove described. Such peptides may be employed as pharmaceuticals. |
申请公布号 |
WO9305802(A1) |
申请公布日期 |
1993.04.01 |
申请号 |
WO1992US07622 |
申请日期 |
1992.09.04 |
申请人 |
MAGAININ PHARMACEUTICALS INC. |
发明人 |
MALOY, W., LEE;KARI, U., PRASAD;WILLIAMS, JON, I. |
分类号 |
A61K38/00;C07K7/06;C07K7/08;C07K14/00;C07K14/46 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|