DIBENZOOXAZEPINE SUBSTITUTED DERIVATIVES AND USE AS ANTI-HYPERALGESICS AND PROCESSES FOR THEIR PRODUCTION

摘要

The invention relates to tricyclic heterocycles of the formula I wherein X is oxy, thio, sulphinyl, sulphonyl, amino, (1-4C)alkylamino or methylene; Y is carbonyl or methylene; each R<1> includes hydrogen, halogeno and various other substituents; each of m and n is 1 or 2; A<1>, alkylene, alkenylene or alkynylene; Het is a 5 or 6 membered heteroaryl group optionally bearing particular substituents; and G is carboxy, 1H-tetrazol-5-yl or a group of the formula:- -CONH-SO<6>R<2> wherein R<2> is (1-4C)alkyl, benzyl or phenyl; and pharmaceutically-acceptable salts thereof, which possess anti-hyperalgesic properties. The invention also relates to processes for the manufacture of said tricyclic heterocycles; and to novel pharmaceutical compositions containing them.