发明名称 |
PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY PURE 4-HYDROXYTETRAHYDRO-2-PYRANONE DERIVATIVES |
摘要 |
<p>A process for the separation of at least one isomer from a mixture of isomers of a tetrahydropyran-2-one, having at least two chiral centres, which comprises selective reaction of at least one isomer with a reagent catalysed by a hydrolase enzyme whereby at least one isomer is preferentially converted into a distinct chemical species from the other isomers so that it is susceptible of separation by an appropriate chemical or physical separation process in which the tetrahydrapyranone is of formula (1), wherein Z is -H or a protecting group susceptible of reaction with the reagent under the influence of the enzyme; and Y is optionally substituted hydrocarbyl.</p> |
申请公布号 |
WO9306235(A1) |
申请公布日期 |
1993.04.01 |
申请号 |
WO1992GB01652 |
申请日期 |
1992.09.10 |
申请人 |
IMPERIAL CHEMICAL INDUSTRIES PLC |
发明人 |
CROSBY, JOHN;BLACKER, ANDREW, JOHN;HERBERT, JOHN, ALBERT, LESLIE |
分类号 |
C07B61/00;C07D309/30;C07D309/32;C07D309/38;C07F7/18;C12P17/06;C12P41/00 |
主分类号 |
C07B61/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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