| 摘要 |
2119379 9306219 PCTABS00021 The invention concerns secondary-metabolite biosynthesis genes from actinomycetes, a method of isolating secondary-metabolite genes, in particular 6-deoxysugar biosynthesis genes, from actinomycetes using the gene probes strD, strE, strL and strM from Streptomyces griseus DSM40236, and structurally related genes, as gene probes to screen out the genes snoT (coding for amphotheronolide-B dTDP D-mycosaminyl transferase), snoD (coding for dTDP D-glucose synthase) and snoM (coding for dTDP 4-keto-6-deoxy-D-glucose isomerase) or one or more secondary-metabolite biosynthesis genes from actinomycetes. The invention also concerns the use of a secondary-metabolite biosynthesis genes thus isolated. |
