Diagnostic Assays for Genetic Mutations Associated with Bovine Leukocyte Adhesion Deficiency

摘要

A point mutation in the CD18 gene responsible for causing bovine leukocyte adhesion deficiency (BLAD) and a silent mutation linked thereto have been identified. Nucleic acid sequences encompassing these mutations serve as bases for testing and identifying cattle alleles attributable to BLAD using any of a variety of diagnostic assays. Suitable nucleic acid probes and primers have also been designed for use in such assays.