TRANSGENIC MHC CLASS I AND CLASS II ANTIGEN-DEFICIENT MAMMALS
摘要
Disclosed are transgenic non-human mammals, the surface of whose cells are deficient in all MHC class II antigens and one or more MHC class I antigens. Also disclosed are the use of mammals as a model system for MHC antigen immunodeficiencies and as a source of universal donor tissue for transplant or somatic cell therapy.
申请公布号
WO9305817(A1)
申请公布日期
1993.04.01
申请号
WO1992US07992
申请日期
1992.09.21
申请人
PRESIDENT AND FELLOWS OF HARVARD COLLEGE;TUFTS UNIVERSITY
发明人
GLIMCHER, LAURIE, H.;PAPAIOANNOU, VIRGINIA, E.;GRUSBY, MICHAEL, J.;JOHNSON, RANDALL, S.
