VERBESSERTES VERFAHREN ZUR ENZYMATISCHEN HERSTELLUNG VON L-2-AMINO-4-METHYLPHOSPHINO-BUTTERSAEURE.

摘要

In a new process for the enzymatic optical resolution of DL-2-amino-4-methylphosphino -butyric acid (I), its N-phenylacetyl deriv. of formula (II) is incubated in aq. or aq.-organic medium with cells of E. coli ATCC 11105 immobilised on/in chitosan. The aq. medium is pref. satd. with butylacetate, t.-butylmethyl ether or methylisobutyl ketone. The incubation is generally carried out at 20-45 deg.C (pref. 30-40 deg.C) and at pH 3-9 (pref. pH 6-8.5).