发明名称 |
VERFAHREN ZUR HERSTELLUNG VON TRANS-1,1,2-TRIPHENYL -BUT-1-EN DERIVATEN. |
摘要 |
In a new process for the prodn. of trans-1,1,2-triphenyl-1-butene derivs. of formula (I), 1,1,2-triphenyl-1-butanol derivs. of formula (II) cure heated in concentrated product is worked up by usual methods. In the formulae, R1 = CH3 or C2H5; R2 = H or OH. HCl used pref. has a concn. of at least 25 wt.% (especially 32-37 wt.%). H2SO4 used pref.has a concn. of at least 40 vol.% (especially 45-50 vo..%). for the treatment of hormone-dependent mammary tumours. Simple process giving trans-(I) directly, practically without the formation of the corresponding cis-isomers.
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申请公布号 |
DE3878394(D1) |
申请公布日期 |
1993.03.25 |
申请号 |
DE19883878394 |
申请日期 |
1988.09.19 |
申请人 |
KLINGE PHARMA GMBH, 8000 MUENCHEN, DE |
发明人 |
WOSCHINA, AXEL, W-8011 POING, DE;GRILL, DR., HELMUT, W-8011 VATERSTETTEN, DE |
分类号 |
C07C217/18;(IPC1-7):C07C217/18 |
主分类号 |
C07C217/18 |
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