发明名称 |
Process for producing acyclic nucleosides. |
摘要 |
<p>Herein is disclosed a novel and industrially advantageous process for synthesizing acyclic nucleosides such as acyclovir and ganciclovir from ribonucleosides, which process comprises adding an acid catalyst and an acid anhydride to a solution of a ribonucleoside such as guanosine and an ester derivative of an acyclic sugar, and heating the mixture, whereby a transglycosilation reaction takes place between the ribose moiety of the ribonucleoside and the ester derivative of the acyclic sugar.</p> |
申请公布号 |
EP0532878(A2) |
申请公布日期 |
1993.03.24 |
申请号 |
EP19920113273 |
申请日期 |
1992.08.04 |
申请人 |
AJINOMOTO CO., LTD. |
发明人 |
SHIRAGAMI, HIROSHI;KOGUCHI, YOSHIHITO;IZAWA, KUNISUKE |
分类号 |
A61K31/52;A61K31/522;A61P31/12;C07D239/26;C07D239/42;C07D473/00;C07D473/18;C07D473/30;C07D473/34;C07H19/16 |
主分类号 |
A61K31/52 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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