Dihydropyridine derivatives useful in antitumor therapy.

摘要

<CHEM> <CHEM> (i) -(CH2)m-CH=CH-Ph, (ii) <CHEM> (iii) <CHEM> (iv) <CHEM> Dihydropyridine derivatives of formula (I), wherein Het is alpha or beta ; A represents a direct linkage, -CH2-,-CH2-CH2-or, when Het is alpha , A may also represent -CH=CH-; R is hydrogen or halogen; C1-C3 alkyl or C1-C3 alkoxy; one of R3 and R4 is C1-C3 alkyl optionally omega substituted by C1-C3 alkoxy and the other is independently C1-C3 alkyl optionally substituted by C1-C3 alkoxy or ( gamma ); R5 is hydrogen or C1-C6 alkyl optionally substituted by -N(RcRd); one of R1 and R2 is a group -OR min wherein R min is C1-C6 alkyl optionally substituted by C1-C3 alkoxy or cyano, and the other is independently a) C1-C3 alkyl, b) a group -OR min , c) a group ( psi ) or d) a group -OR<IV> wherein R<IV> is hydrogen or a substituent selected from (i), (ii), (iii) and (iv), are useful antitumor activity promoting agents.