发明名称 1,4-BIS-(AMINO-HYDROXYALKYLAMINO)-ANTHRAQUINONES FOR INHIBITING PROTEIN KINASE C
摘要 The present invention provides novel substituted anthraquinones having the formula <IMAGE> wherein R1 and R2 are independently H, alkyl, aryl, or arylalkyl; m and n are independently 1, 2, or 3; X is H, OH, NR3R4, Cl, Br, I, F, alkyl, aryl alkoxy, aroxy, COOR5, or CONR6R7; R3, R4, R5, R6, and R7 are independently H, lower alkyl or aryl useful for inhibiting protein kinase C and treating conditions related to, or affected by inhibition of protein kinase C, particularly cancer tumors, inflammatory disease, reperfusion injury, and cardiac dysfunctions related to reperfusion injury.
申请公布号 EP0509088(A4) 申请公布日期 1993.03.24
申请号 EP19920900630 申请日期 1991.10.30
申请人 SPHINX PHARMACEUTICALS CORPORATION 发明人 JIANG, JACK, B.;JOHNSON, MARY, GEORGE
分类号 A61K31/135;A61K31/165;A61K31/19;A61K31/24;A61P7/02;A61P9/00;A61P29/00;A61P35/00;A61P43/00;C07C;C07C225/34;C07C225/36;C07C229/74;C07C237/06;C12N9/99 主分类号 A61K31/135
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