| 摘要 |
Piperidinyl, pyrrolidinyl, azepinyl and piperazinyl pyridazines of formula <IMAGE> (I) wherein one or two carbon atoms of the <IMAGE> moiety may be substituted with C1-4alkyl, C1-4alkyloxy or two carbon atoms of the CH2 groups of said moiety may be bridged with a C2-4alkanediyl radical; X represents CH or N; R1 represents hydrogen, C1-4alkyl, halo, hydroxy, trifluoromethyl, cyano, C1-4alkyloxy, C1-4alkylthio, C1-4alkylsulfinyl, C1-4alkylsulfonyl, C1-4alkyloxycarbonyl, C1-4alkylcarbonyl or aryl; R2 and R3 each independently represent hydrogen or C1-4alkyl; Alk represents C1-4alkanediyl; R4 and R5 each independently represent hydrogen, C1-4alkyl or halo; and Het represents <IMAGE> (a) <IMAGE> (b) <IMAGE> (c) <IMAGE> (d) <IMAGE> (e) <IMAGE> (f) <IMAGE> (g) <IMAGE> (h) the addition salts and stereochemically isomeric forms thereof, said compounds having antipicornaviral activity. Pharmaceutical compositions containing these compounds as active ingredient, and a method of preparing said compounds and pharmaceutical compositions.
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