DIAMINO-ANDROSTANE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

The invention relates to new 6,16-diamino-androstane derivatives of the formula (I) (I) and physiologically acceptable di- and monoquaternary salts thereof of the formulae (Ia) (Ia) (Ib) (Ib) (Ic) (Ic) and (Id) (Id) wherein Y is hydrogen or an OAc group, Ac is an alkylcarbonyl group having from 1 to 4 carbon atoms in the alkyl moiety, A is methylene or a group of the formula , in which R1 is alkyl having from 1 to 4 carbon atoms, B is methylene, or a group or , in which R1 is as defined above and R2 is a -CH2-CH2-COOR1 group, and n is 1 or 2, m is 1, 2 or 3, B1 is a group or , in which R1 and R2 are as defined above, R3 is alkyl or alkenyl having from 1 to 4 carbon atoms, Z is halogen or sulfonyloxy.