发明名称 CYCLIC HEXAPEPTIDE COMPOUND
摘要 Compounds of the formula <CHEM> wherein R1 is hydrogen or hydroxyl; R2 is hydrogen; hydroxyl or methyl, R3 is hydrogen or hydroxyl; R4 is C5-C23 alkyl, C5-C23 alkenyl, aryl or substituted aryl; R5 is -CH2OH, -CH(CH3)OH, -CH(CH2CONH2)OH; R6 is -CH2OH or -CH(CH3)OH; R is -CH2OH or -CH(CH3)OH; provided that when R4 is -(CH2)8CH(CH3)CH2CH(CH3)C2H5, R5 is -CH2OH or -CH(CH3)OH. The compounds are useful as antimicrobial agents, especially as antifungal agents.
申请公布号 JPH0570495(A) 申请公布日期 1993.03.23
申请号 JP19920031149 申请日期 1992.02.19
申请人 MERCK & CO INC 发明人 MIRUTON ERU HAMONDO;JIEEMUSU BUI HETSUKU;ROBAATO EE ZANBIASU
分类号 A61K38/00;A61P31/04;A61P31/10;A61P33/00;C07K7/56 主分类号 A61K38/00
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