发明名称 |
HETEROARYL-3-OXO-PROPANENITRILE DERIVATIVES USEFUL IN THE TREATMENT OF RHEUMATOID ARTHRITIS AND OTHER AUTOIMMUNE DISEASES |
摘要 |
Heteroaryl-3-oxo-propanenitrile derivatives of formula (I) <IMAGE> (I) wherein X represents an oxygen atom or a -CH(R4)-, -O-CH(R4)-, -S(O)n-CH(R4)-, -CH(R4)-O-, -CH(R4)-S(O)n- -CH(R4)-CH2- group wherein n is 0, 1 or 2; R1 represents C1-C6 alkyl, pyridyl or unsubstituted or substituted phenyl; R2, R3, and R4 are as herein defined; and Q is hydrogen, carboxy, C2-C7-alkoxycarbonyl or a -CON(Ra)Rb group, Ra and Rb being as defined herein; and their pharmaceutically acceptable salts are useful in the preparation of pharmaceutical compositions active in the treatment of autoimmune diseases.
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申请公布号 |
US5196445(A) |
申请公布日期 |
1993.03.23 |
申请号 |
US19900613482 |
申请日期 |
1990.10.31 |
申请人 |
FARMITALIA CARLO ERBA SRL |
发明人 |
DORIA, GIANFEDERICO;ISETTA, ANNA M.;FERRECCIO, RINALDO;FERRARI, MARIO;FORNASIERO, MARIA C.;TRIZIO, DOMENICO |
分类号 |
C07D231/54;A61K31/415;A61K31/44;A61P37/00;C07D491/048;C07D495/04 |
主分类号 |
C07D231/54 |
代理机构 |
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主权项 |
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地址 |
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