Water and solvent soluble axial hydroxy and mono- and di- carboxylic acid derivatives having high tumor activity

摘要

Platinum complexes are disclosed in which the formula is <IMAGE> wherein A and B are each independently ammine or monodentate amine, or A and B taken together represent a bidentate amine, and A and B are coordinated to the platinum atom through their nitrogen atom; X and Y are each independently halogen; R' is C1-C20 alkanoyl, aroyl, heteroaroyl, or a group selected from the group consisting of <IMAGE> <IMAGE> <IMAGE> wherein u' is an integer from 1 to 5; and R'' is hydrogen with the proviso that A, B, X, and Y are structually equatorial substituents with respect to OR'-Pt-OR''. These platinum complexes show antitumor activity with relatively lower kidney or bone marrow toxicity.