| 摘要 |
The derivatives of the formula: <IMAGE> (I) wherein: R1 is H or C1-C4 alkyl; X is either an oxygen atom, in which case R2=H or halogen, or a methylene group or a -CH=CH- group, in which case R2=H; n is 1 or 2 when X is an oxygen atom or a methylene group and 0 or 1 when X is a -CH=CH- group; each of R3 and R4 is independently H, C1-C4 alkyl, C4-C7 cycloalkyl, phenyl or benzyl; R5 is H or C1-C4 alkyl; R6 is C1-C4 alkyl, CHF2, CF3, CF3CF2, C4-C7 cycloalkyl, phenyl or benzyl; R4 and R6 may further form together a -(CH2)3- or -(CH2)4-chain; R5 and R6 may further form together a -(CH2)4-or -(CH2)5-chain; and R7 is H, C1-C4 alkyl, C2-C5 acyl or benzyl, useful as drugs, prepared by cyclizing N ethoxy carbonyl anilines with substituted 1, 3 dioxolane-2-ones.
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