LIPOSOM-ANTHRACHINON-ARZNEIMITTEL-ZUSAMMENSETZUNG UND HERSTELLUNG.
摘要
<p>A drug/liposome composition comprises an aqueous suspension of liposomes and, entrapped in the lipid bilayer region of the liposomes, an anthraquinone drug containing quinone and hydroquinone functionalities on adjacent anthracene rings. An iron-specific trihydroxamic chelating agent contained in the bulk aqueous phase of the suspension and a lipophilic free-radical scavenger contained in the bilayer region of the liposome cooperate to reduce chemical modification of both drug and lipid components of the composition. The compositions can be used for administering doxorubicin intravenously to humans, with significantly reduced incidence of side effects, and for treating primary and secondary neoplasms of the liver.</p>
申请公布号
DE3782492(T2)
申请公布日期
1993.03.18
申请号
DE19873782492T
申请日期
1987.01.09
申请人
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, JERUSALEM/JERUSALAJIM, IL;HADASSAH MEDICAL ORGANIZATION, JERUSALEM, IL
发明人
BARENHOLZ, YECHEZKEL, JERUSALEM 93707, IL;GABIZON, ALBERTO, SAN FRANCISCO, CA 94123, US