发明名称 |
4-(4-(4-(4-HYDROXYPHENYL)-1-PIPERAZINYL)PHENYL)-5-METHYL-3H- 1,2,4-TRIAZOL-3-ONE DERIVATIVES |
摘要 |
2-[2-(4-chlorophenyl)-2-(hydroxy or oxo)ethyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl] -5-methyl-3H-1,2,4-triazol-3-one having the formula <CHEM> wherein X represents C=O or CHOH, for use as 5-lipoxygenase inhibitors. Pharmaceutical compositions, processes for preparing said compounds and compositions; and a method of treating leukotriene mediated diseases. |
申请公布号 |
AU2281992(A) |
申请公布日期 |
1993.03.18 |
申请号 |
AU19920022819 |
申请日期 |
1992.09.07 |
申请人 |
JANSSEN PHARMACEUTICA N.V. |
发明人 |
JAN HEERES;JOSEPH HECTOR MOSTMANS;JOHAN RENE MARK BEETENS |
分类号 |
A61K31/41;A61K31/495;A61P1/00;A61P11/00;A61P17/00;A61P37/08;C07D249/12 |
主分类号 |
A61K31/41 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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