| 摘要 |
<p>A compound having formula (I), wherein R?4 and R5¿ independently are hydrogen, halogen, CF¿3?, CN, NO2 or SO2NR?1R2¿ wherein R1 is hydrogen or straight, C¿1-6?-alkyl which may be branched or cyclic, R?2¿ is hydrogen or straight, C¿1-6?-alkyl which may be branched or cyclic, or wherein R?1 and R2¿ together represent -(CH¿2?)n-A-(CH2)m-, wherein A is O, S, CH2 or NR?I¿, wherein RI is H, C¿1-6?-alkyl which may be straight, branched or cyclic, n is 0, 1, 2, 3, 4, 5 and m is 0, 1, 2, 3, 4, 5; Q is NOH, or O; Z = O, S, N-R?II¿, (a), (b), (c), wherein R?II, RIII, RIV and RV¿ independently are hydrogen, benzyl, C¿1-6?-acyl, C1-6-alkoxy which may be branched or cyclic, or C1-6-alkyl which may be branched or cyclic; X is -(CH2)o- wherein o is 0, 1, 2, or 3; Y is -(CH2)p- wherein p is 0, 1, 2, or 3; α and β indicate attachment points, and a method of treating disorders of a mammal, including a human, responsive to the blockade of glutamic and aspartic acid receptors, with the same.</p> |
