发明名称 |
IMPROVEMENTS IN OR RELATING TO MODIFIED HAPTENS USEFUL AS IMAGING AND THERAPEUTIC AGENTS |
摘要 |
The present invention discloses a method for preserving a chemical compound associated with or attached to a strong beta emitter in an aqueous solution from radiolytic degradation by adding thereto a reducing oxidizing agent, preferably ascorbate ion, as a radioprotectant. For instance, degradation of haptens radiolabelled with a strong beta emitter, such as <90>Yttrium, and stored in an aqueous solution can be substantially reduced by adding ascorbate ion to the solution. A method for preventing radiolytic degradation of compounds during the radiolabelling process is also provided. |
申请公布号 |
WO9302652(A3) |
申请公布日期 |
1993.03.18 |
申请号 |
WO1992US06360 |
申请日期 |
1992.07.31 |
申请人 |
HYBRITECH INCORPORATED |
发明人 |
BALASUBRAMANIAN, PAVANASAM, N.;LOLLO, CHARLES, P.;WANEK, PHILIP, M. |
分类号 |
A61K51/04;A61K51/12 |
主分类号 |
A61K51/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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