SUBSTITUIERTE PYRIDYLETHANOLAMINE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS LEISTUNGSFOERDERER BEI TIEREN.

摘要

1-Pyridyl-2-amino -ethanol derivs. of formula (I), their physiologically tolerable salts and N-oxides are new; where R1 = CN, COOR8 or CONR9R10; R2 = opt.substd. alkyl; R3 = H, alkyl or alk(en)yl; R4 = H, opt. substd. alkyl or alkenyl, or together R3 and R4 complete an opt. substd. heterocycle, R5 = OH, acyloxy or alkoxy, R6 = H or alkyl; R7 = H, cycloalkyl, opt. substd. (ar)aklyl, aryl or heterocyclyl, or together R6 and R7 complete an opt. substd. heterocycle, R8 = alkyl; R9 and R10 are each H, alkyl or alkenyl, or together complete an opt. substd. heterocycle. Also new are the intermediate ketones of formulae (II), (IV) and (V); where X = halo. Cpds. (II) are reacted with HNR6R7, and the keto product reduced, pref. with NaBH4 or NaBH3cn at -20 to 100 deg.C, to give (I; R5 = OH). This can be acylated or alkylated conventionally.