N-substituted heterocyclic derivatives as angiotensin II inhibitors.

摘要

The invention relates to N-substituted heterocyclic derivatives of formula: <IMAGE> in which: - R1 and R2 are similar or different and each independently represent hydrogen or a group chosen from a C1-C6 alkyl, a C1-C4 alkoxy, an amino, an aminomethyl, a carboxyl, an alkoxycarbonyl in which the alkoxy is C1-C4, a cyano, a tetrazolyl, a methyltetrazolyl, a methylsulphonylamino, a trifluoromethylsulphonylamino, a trifluoromethylsulphonylaminomethyl, an N-cyanoacetamido, an N-hydroxyacetamido, an N-(4-carboxyl-1,3-thiazol-2-yl)acetamido, a ureido, a 2-cyanoguanidinocarbonyl, a 2-cyanoguanidinomethyl, an imidazol-1-ylcarbonyl or a 3-cyano-2-methylisothioureidomethyl, provided that at least one of the substituents R1 or R2 is other than hydrogen; - R3 represents a hydrogen, a C1-C6 alkyl which is unsubstituted or substituted by one or a number of halogen atoms, a C2-C6 alkenyl, a C3-C7 cycloalkyl, a phenyl, a phenylalkyl in which the alkyl is C1-C3 or a phenylalkenyl in which the alkenyl is C2-C3, the said phenyl groups being unsubstituted or substituted one or a number of times by a halogen atom, a C1-C4 alkyl, a C1-C4 haloalkyl, a C1-C4 polyhaloalkyl, a hydroxyl or a C1-C4 alkoxy; - R4 represents a C1-C6 alkyl which is unsubstituted or substituted by one or a number of halogen atoms; - R5 represents a cycloalkyl or a cycloalkylmethyl, the said cycloalkyl being C3-C7 unsubstituted or substituted by one or a number of halogen atoms; - or R4 and R5 each represent a cyclopropyl; - X represents an oxygen atom or a sulphur atom; - z and t are zero or one is zero and the other represents one; and its salts. Application: Angiotensin II antagonists.