Cellular immunity vaccines from bacterial toxin-antigen conjugates.

摘要

Recombinant hybrid proteins having two primary components. The first component is a modified bacterial toxin that has translocating ability, while the second component is a polypeptide or protein that is exogenous to an antigen-presenting cell. The hybrid has the ability to be internalized by an antigen-presenting cell, where the hybrid is subsequently processed and an antigenic segment of the hybrid presented on the surface of the antigen-presenting cell, where the segment elicits an immune response by cytotoxic T lymphocytes. <IMAGE>