发明名称 |
RAF PROTEIN KINASE THERAPEUTICS |
摘要 |
It is a general object of this invention to provide a DNA segment comprising a Raf gene in an antisense orientation downstream of a promoter. It is a specific object of this invention to provide a method of inhibiting Raf expression comprising expressing an antisense Raf gene in a cell such that said Raf expression is inhibited. It is a further object of the invention to provide a method of inhibiting Raf kinase activity comprising replacement of a serine or threonine amino acid within the Raf gene for a non-phosphorylated amino acid. |
申请公布号 |
AU2552492(A) |
申请公布日期 |
1993.03.16 |
申请号 |
AU19920025524 |
申请日期 |
1992.08.21 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DE |
发明人 |
ULF R RAPP;HARALD APP;STEPHEN M STORM |
分类号 |
A61K38/00;C07K14/82;C12N15/113 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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