SYNTHETIC UNRANDOMIZATION OF OLIGOMER FRAGMENTS

摘要

PCT No. PCT/US92/07121 Sec. 371 Date Feb. 22, 1994 Sec. 102(e) Date Feb. 22, 1994 PCT Filed Aug. 21, 1992 PCT Pub. No. WO93/04204 PCT Pub. Date Mar. 4, 1993Methods useful for the determination of oligomers which have specific activity for a target molecule from a pool of primarily randomly assembled subunits are provided. The disclosed methods involve repeated syntheses of increasingly simplified sets of oligomers coupled with selection procedures for determining oligomers having the highest activity. Freedom from the use of enzymes allows the application of these methods to any molecules which can be oligomerized in a controlled fashion.