| 摘要 |
A process for the preparation of a compound of the formula <IMAGE> I wherein R1 and R2 are individually selected from the group consisting of hydrogen, halogen, -CF3, alkyl, alkoxy and alkylthio of 1 to 8 carbon atoms, alkenyl and alkynyl of 2 to 8 carbon atoms, -SO2alk and alk is alkyl of 1 to 8 carbon atoms, optionally substituted aryl, aryloxy and arylthio of 6 to 18 carbon atoms and optionally substituted heteroaryl, heteroaryloxy and heterocyclic of 5 to 6 ring members, R3 is selected from the group consisting of alkyl of 1 to 8 carbon atoms, alkenyl and alkynyl of 2 to 8 carbon atoms, aryl of 6 to 18 carbon atoms and alkoxyalkoxyalkyl of 3 to 14 carbon atoms, X is selected from the group consisting of -O-, -S- and -NR4-, R4 is selected from the group consisting of hydrogen, alkyl, alkenyl and alkynyl of up to 8 carbon atoms, -SO2 alkyl, -SO2 alkenyl and -SO2 alkynyl of up to 8 carbon atoms and optionally substituted aryl and -SO2 aryl of 6 to 18 carbon atoms, the double bond between the heterocycle of 5 member ring and the aromatic nucleus is of E and/or Z geometry comprising reacting a halide of the formula <IMAGE> II wherein R3 is as defined above and Hal is hydrogen with a compound of the formula <IMAGE> III wherein X, R1 and R2 have the above definitions in the presence of a base to obtain the corresponding product of formula I in the form of a mixture of isomers and optionally separating the isomers and novel intermediates of formula II.
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