摘要 |
Positive inotropic and lusitropic 3,5-dihydroimidazo[2,1-b]quinazolin-2(1H)-one derivatives of formula <CHEM> the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein R is hydrogen, C1-6alkyl, phenyl; substituted phenyl; pyridinyl; or thienyl optionally substituted with halo or C1-6alkyl; R<1> is hydrogen of C1-6alkyl; R<2> is hydrogen, C1-6alkyl, hydroxyC1-6alkyl or phenyl; or R<1> and R<2> taken together may also form a C1-5alkanediyl radical; X is a radical of formula =O (a), =N-O-R<3> (b),or =CH-R<4> (c); R<3> is hydrogen, tri(C1-6alkyl)silyl or C1-6alkyl optionally substituted with COOH, COOC1-4alkyl, CONR<5>R<6> or COOCH2CONR<7>R<8>; R<4> is COOH, COOC1-4alkyl, CONR<5>R<6>, COOCH2CONR<7>R<8> or C1-6alkyl optionally substituted with COOH, COOC1-4alkyl, CONR<5>R<6> or COOCH2CONR<7>R<8>. Pharmaceutical compositions containing said compounds as an active ingredient. Methods of preparing said compounds and pharmaceutical compositions. |