INOSOSE DERIVATIVES, PRODUCTION AND USE THEREOF

摘要

Disclosed is a novel inosose compound represented by the general formula: wherein X<1> and X<2> are both halogen; X<1> is hydrogen and X<2> is halogen; or X<1> is -SQ<1> and X<2> is -SQ<2> (each of Q<1> and Q<2> is lower alkyl or Q<1> and Q<2> may form lower alkylene), R<1> is a protective group for hydroxyl and Y is =O, =N-Z (Z is hydroxyl which may be protected) or @ @@HA (A is hydrogen or an amine residue), particulaly to the compound wherein the symbol Y is oxygen. The inosose compound is useful as intermediates for production of valiolamine and the N-substituted derivatives thereof, which have potent alpha -glucosidase inhibiting activities and are useful as preventives or therapeutics for symptoms of hyperglycemia and various diseases derived therefrom in human and animals, such as diabetes, obesity and hyperlipemia.