| 摘要 |
<p>A novel pyrimidine derivative having an excellent antitumor activity, which is represented by the following general formula (I) or a pharmacologically acceptable salt thereof: <CHEM> wherein R<1> represents a hydroxyl or amino group; R<2> represents a phenylene, pyridinediyl, thiendiyl, furandiyl or thiazoldiyl group, -CO2R<5> and -CO2R<6> may be the same or different from each other and each represents a carboxyl group or a carboxylic acid ester, the part &rdurule& X-Y-Z- represents &rdurule& N-CH2-CH2-, &rdurule& N-CH=CH- or &rdurule& CH-CH2-CH2-, A represents an oxygen atom, a group represented by the formula: <CHEM> (wherein R<3> and R<4> may be the same or different from each other and each represents a hydrogen or halogen atom or a hydrocarbon group which may be substituted, or alternatively R<3> and R<4> may be united to form an alkylidene group which may be substituted) or a group represented by the formula: <CHEM> (wherein R<7><0> represents a hydrogen atom or a hydrocarbon group), and n is an integer of 1 to 3, provided that the compound in which R<1> represents oxygen, and hydrogen is attached to nitrogen at 3-position is included in the above shown definition, a process for preparation the same, and an antitumor drug containing the same.</p> |
