N,N',N'-trisubstituted -5-bis-aminomethylene-1,3-dioxane-4,6-dione inhibitors of acyl-CoA: cholesterol-acyl transferase.

摘要

A compound of the formula: <CHEM> in which X, Y and Z are, independently, hydrogen, halogen, hydroxy,nitro, cyano, carboxyl, trifluoromethyl, phenyl, amino, alkylamino, dialkylamino, alkyl or alkoxy; R1 is alkyl, alkenyl, cycloalkyl, phenyl, benzyl or substituted phenyl or benzyl, R2 is <CHEM> or a pharmaceutically acceptable salt thereof, are ACAT inhibitors.